Publications

Publications of this Project

  1. Evans DS. Target Discovery for Drug Development Using Mendelian Randomization. Methods Mol Biol. 2022;2547:1-20. doi:10.1007/978-1-0716-2573-6_1 

  2. Kaya S, Schurman CA, Dole NS, Evans DS, Alliston T. Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses. J Bone Miner Res. 2022;37(4):804-817. doi:10.1002/jbmr.4516 

  3. Evans DS, O'Leary MN, Murphy R, et al. Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs. JBMR Plus. 2021;5(3):e10466. Published 2021 Feb 16. doi:10.1002/jbm4.10466 

  4. Duan Y, Evans DS, Miller RA, Schork NJ, Cummings SR, Girke T (2020) signatureSearch: environment for gene expression signature searching and functional interpretation. Nucleic Acids Res: gkaa878, 1-14. PubMed

  5. Lombard DB, Kohler WJ, Guo AH, Gendron C, Han M, Ding W, Lyu Y, Ching T-T, Wang F-Y, Chakraborty TS, Nikolovska-Coleska Z, Duan Y, Girke T, Hsu A-L, Pletcher SD, Miller RA (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv: 6, 1-13. PubMed

  6. McCorrison J, Girke T, Goetz LH, Miller RA, Schork NJ (2019) Genetic Support for Longevity-Enhancing Drug Targets: Issues, Preliminary Data, and Future Directions. J Gerontol A Biol Sci Med Sci: 74, S61-S71. PubMed

  7. Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, et al (2019) A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun 10: 3669. PubMed

  8. Shah P, Kendall F, Khozin S, Goosen R, Hu J, Laramie J, Ringel M, Schork N. Artificial intelligence and machine learning in clinical development: a translational perspective. NPJ Digit Med. 2019 Jul 26;2:69. doi: 10.1038/s41746-019-0148-3. eCollection 2019. Review. PMID: 31372505 

  9. Schork NJ. Artificial Intelligence and Personalized Medicine. Cancer Treat Res. 2019;178:265-283. doi: 10.1007/978-3-030-16391-4_11. PMID: 31209850

  10. Schork NJ, Raghavachari N; Workshop Speakers and Participants. Report: NIA workshop on translating genetic variants associated with longevity into drug targets. Geroscience. 2018 Dec;40(5-6):523-538. doi: 10.1007/s11357-018-0046-7. Epub 2018 Oct 29. PMID: 30374935 

  11. Schork AJ, Schork MA, Schork NJ. Genetic risks and clinical rewards. Nat Genet. 2018 Sep;50(9):1210-1211. doi: 10.1038/s41588-018-0213-x. No abstract available. PMID: 30158681 

  12. Rangan AV, McGrouther CC, Kelsoe J, Schork N, Stahl E, Zhu Q, Krishnan A, Yao V, Troyanskaya O, Bilaloglu S, Raghavan P, Bergen S, Jureus A, Landen M; Bipolar Disorders Working Group of the Psychiatric Genomics Consortium. A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data. PLoS Comput Biol. 2018 May 14;14(5):e1006105. doi: 10.1371/journal.pcbi.1006105. eCollection 2018 May. PMID: 29758032

  13. Choi Y, Chan AP, Kirkness E, Telenti A, Schork NJ. Comparison of phasing strategies for whole human genomes. PLoS Genet. 2018 Apr 5;14(4):e1007308. doi: 10.1371/journal.pgen.1007308. eCollection 2018 Apr. PMID: 29621242 

  14. Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites. Nat Genet. 2017 Apr;49(4):568-578. doi: 10.1038/ng.3809. Epub 2017 Mar 6. PMID: 28263315

  15. Ding KF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ. Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses. Oncotarget. 2017 Apr 25;8(17):27786-27799. doi: 10.18632/oncotarget.15347. PMID: 28212541 

  16. Ding KF, Petricoin EF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ. Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis. Oncotarget. 2017 Dec 15;9(4):5044-5057. doi: 10.18632/oncotarget.23495. eCollection 2018 Jan 12. PMID: 29435161

  17. Zillikens MC, Demissie S, Hsu Y-H, Yerges-Armstrong LM, Chou W-C, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, et al (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun 8: 80. PubMed
  18. Backman T, Evans D, Girke T (2017) Large-scale Bioactivity Analysis of the Small-Molecule Assayed Proteome. PLoS ONE: 12, e0171413. PubMed
  19. Backman TW, Girke T (2016) systemPipeR: NGS workflow and report generation environment. BMC Bioinformatics: 17, 1-8. PubMed
  20. Backman TW, Girke T (2016) bioassayR: Cross-Target Analysis of Small Molecule Bioactivity. J Chem Inf Model: Epub ahead of print. PubMed

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  2. Brion M-JA, Shakhbazov K, Visscher PM (2013) Calculating statistical power in Mendelian randomization studies. Int J Epidemiol 42: 1497–1501 PubMed
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  6. Broer, L, Buchman, AS, Deelen, J, Evans, DS, Faul, JD, et al. (2014). GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy. J Gerontol A Biol Sci Med Sci, 70(1):110-118. PubMed
  7. Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, Atzmon G, Barzilai N, Franceschi C, Owen AB, et al (2015) Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. PLoS Genet 11: e1005728 PubMed
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